Preferred Nutrition PEA 400 mg is a chronic pain relief formula made from fractionated non-GMO safflower seed oil. Studies have shown that palmitoylethanolamide (PEA), a fatty-acid-like compound, offers analgesic, neuroprotective, and anti-neuroinflammatory benefits. PEA occurs naturally in certain foods and is made within the body as part of the endocannabinoid system. This formula features micronized PEA for improved solubility and absorption.